The Fernsehturm (TV tower) at Alexanderplatz in Mitte is among the tallest structures in the European Union at 368 meters (1,207 ft). Built in 1969, it is visible throughout most of the central districts of Berlin. The city can be viewed from its 204 m (669 ft) high observation floor. Starting here the Karl-Marx-Allee heads east, an avenue lined by monumental residential buildings, designed in the Socialist Classicism Style of the Joseph Stalin era. Adjacent to this area is the Rotes Rathaus (City Hall), with its distinctive red-brick architecture. The previously built-up part in front of it is the Neptunbrunnen, a fountain featuring a mythological scene.

The East Side Gallery is an open-air exhibition of art painted directly on the last existing portions of the Berlin Wall. It is the largest remaining evidence of the city's historical division. It has recently undergone a restoration.
The Brandenburg Gate is an iconic landmark of Berlin and Germany. It also appears on German euro coins (10 cent, 20 cent, and 50 cent). The Reichstag building is the traditional seat of the German Parliament, renovated in the 1950s after severe World War II damage. The building was again remodeled by British architect Norman Foster in the 1990s and features a glass dome over the session area, which allows free public access to the parliamentary proceedings and magnificent views of the city.

The Gendarmenmarkt, a neoclassical square in Berlin whose name dates back to the Napoleonic occupation of the city, is bordered by two similarly designed cathedrals, the Französischer Dom with its observation platform and the German Cathedral. The Konzerthaus (Concert Hall), home of the Berlin Symphony Orchestra, stands between the two cathedrals.

The Berlin Cathedral, a Protestant cathedral and the third church on this site, is located on the Spree Island across from the site of the Stadtschloss and adjacent to the Lustgarten. A large crypt houses the remains of some of the earlier Prussian royal family. Like many other buildings, it suffered extensive damage during the Second World War. St. Hedwig's Cathedral is Berlin's Roman Catholic cathedral.

Unter den Linden is a tree lined east-west avenue from the Brandenburg Gate to the site of the former Berliner Stadtschloss, and was once Berlin's premier promenade. Many Classical buildings line the street and part of Humboldt University is located there. Friedrichstraße was Berlin's legendary street during the Roaring Twenties. It combines twentieth century traditions with the modern architecture of today's Berlin.
Potsdamer Platz is an entire quarter built from scratch after 1995 after the Wall came down. To the west of Potsdamer Platz is the Kulturforum, which houses the Gemäldegalerie, and is flanked by the Neue Nationalgalerie and the Berliner Philharmonie. The Memorial to the Murdered Jews of Europe, a Holocaust memorial, is situated to the north.
The area around Hackescher Markt is home to the fashionable culture, with countless clothing outlets, clubs, bars, and galleries. This includes the Hackesche Höfe, a conglomeration of buildings around several courtyards, reconstructed around 1996. Oranienburger Straße and the nearby New Synagogue were the center of Jewish culture before 1933. Although the New Synagogue is still an anchor for Jewish history and culture, Oranienburger straße and surrounding areas are increasingly known for the shopping and nightlife.

The Straße des 17. Juni, connecting the Brandenburg Gate and Ernst-Reuter-Platz, serves as central East-West-Axis. Its name commemorates the uprisings in East Berlin of 17 June 1953. Approximately half-way from the Brandenburg Gate is the Großer Stern, a circular traffic island on which the Siegessäule (Victory Column) is situated. This monument, built to commemorate Prussia's victories, was relocated 1938-39 from its previous position in front of the Reichstag.

The Kurfürstendamm is home to some of Berlin's luxurious stores with the Kaiser Wilhelm Memorial Church at its eastern end on Breitscheidplatz. The church was destroyed in the Second World War and left in ruins. Near by on Tauentzienstraße is KaDeWe, claimed to be continental Europe's largest department store. The Rathaus Schöneberg, where John F. Kennedy made his famous "Ich bin ein Berliner!" speech, is situated in Tempelhof-Schöneberg.

West of the center, Schloss Bellevue is the residence of the German President. Schloss Charlottenburg, which was burnt out in the Second World War and largely destroyed, has been rebuilt and is the largest surviving historical palace in Berlin.

The Funkturm Berlin is a 150 m (490 ft) tall lattice radio tower at the fair area, built between 1924 and 1926. It is the only observation tower which stands on insulators, and has a restaurant 55 m (180 ft) and an observation deck 126 m (413 ft) above ground, which is reachable by a windowed elevator.